Medical Instrumentation Signal Chains for Life Science Applications

The world of medical science is very quickly evolving and adapting for the future. Medical devices are becoming increasingly high-tech, in turn needing to be built with the most modern internal parts and systems.

The components that Analog Devices manufactures are some of the most efficient, smallest, and most accurate available on the market today - making them ideal for the medical industry. Below, learn more about specific Analog Devices offerings for specialized applications such as ventilators, in vitro diagnostics, dialysis, and infusion.

 

Jump to:  Ventilators   |    IVD - In Vitro Diagnostics  |  Kidney Dialysis   |   Infusion Pumps

Ventilators

As extremely critical medical devices, ventilators support or assist a patient’s breathing. Simply defined, they consist of an electrically driven turbine or diaphragm to mechanically deliver air to a patient’s lungs, and an embedded system to control pressure and flow. They have the ability to regulate oxygen levels, heat and/or humidify incoming air, and pressurize air according to patient needs. At a system level, ventilators need to:

  • •  Have many modes of operation to target various and dynamic patient needs
  • •  Have fast and precise adjustment of pressure and flow
  • •  Have highly adjustable and accurate turbine speeds

In the following flow charts and table, see the signal chain of a typical ventilator and recommended Analog Devices parts for your design.

 

Body Image 1-ADI-IGG-Reference-Designs-for-Life-Science

 

Table of Recommended Parts


Function
Part Number
Design Consideration

Temp, Pressure, Flow interface

 AD7124-4 (integrated)

 


 Low power, low noise, integrated analog
 front end for high precision measurements
 LTC2983 (integrated)
 Multi-Sensor High Accuracy Digital   Temperature Measurement System 
 AD7195 (discrete pressure)

 Bridge optimized ADC. 4.8 kHz, Ultralow   Noise, 24-Bit Sigma-Delta ADC with PGA   and AC Excitation
 LTC2487 (discrete pressure)
 16-Bit 2-/4-Channel ∆Σ ADC with
 PGA,Easy Drive and I2C Interface
   AD8290 (discrete pressure)
 AD8295
 Precision Instrumentation Amplifier with   Signal Processing Amplifiers

Multimodal Sensor

 ADPD4000  8 input channels and 12 programmable       timeslots. Ideal for designs that are     combining multiple measurements (optical,
 thoracic impedance, ECG, temp)

Optical Front End

 ADPD1080  Photometric analog front end, including X3
 LED drivers for designs that only require
 optical based measurements

Impedance Front End

 AD5940  High precision impedance and
 electrochemical front end for designs that
 require more complex impedance
 measurement, such as EDA and body
 impedance analysis
 

Biopotential Front End

 AD8233  Low noise single lead ECG front end 

Anemometer amps

 LT6370
 AD8422
 LT1468
 Constant Temperature Anemometer.   Op amps required (rather than in-amps)
 to quickly/accurately close the dynamic
 loop. Typical specs GBP >80MHz,
 Slew >20V/us, Vos <30uV

General Purpose Reference

 ADR45xx  Ultralow noise, high accuracy reference 

Video DAC

 ADV7510  330MHz Triple 8-Bit High Speed Video
 DAC
 

HDMI Transceiver

 ADV7510  Deep Color HDMI® 1.3 Transmitter
 with CEC
 

Vibration Sensor

 ADcmXL3021  Wide Bandwidth, low noise, triaxle   accelerometer

uC/DSP

 ADSP-SC57x
 ADSP-CM40X
 
 Single/dual core sharc+ ARM Cortex
 A5
 Ultra low power ARM Coretex-M4F
 MCU with Integrated Power
 management

CDC

 AD7745  Cap to digital touch screen controller

Table of Recommended Parts: Isolation


Function
Part Number
Design Consideration

Digital Isolators

 ADuM220ADuM221,
 ADuM240ADuM241ADuM242,
 ADuM260/61/62/63
 Improved Radiated Emissions
 performance, and Surge capability

USB Isolator 

 ADuM4160
 In 2020: ADuM4165


 ADuM4160 will likely have emissions
 challenges
 ADuM4165 designed for low emissions and   high surge

Isolated USB Transceiver with isolated power

 LTM2884  2500Vrms Isolation, integrated DC/DC   converter, and auto configuration of bus
 speed

Isolated RS-232 

 Discrete Approach: Digital Isolator +   Transceiver  ADM32512E only 2.5 kVrms, no IEC
 60601-1 certification

Isolated RS-485

 ADM2490E
 ADM2481E
 5 kVrms but no IEC 60601-1
 certification
 

Isolated RS-485 + Power

 ADM2867E  ADM2867E designed for low  emissions
 LTM2885 has exceptional EMC
 performance and high surge 

CAN Isolator

 ADM3056E
 ADM3057E
 LTM2889
 Isolated CAN transceivers. ADM3065E   (5.7kV),  AD3057E (2kV) 12Mbps data rate.
 LTM2889 2.5kV up to 4Mbps datarate

Isolated Gate Driver

 ADuM412x  Isolated precision gate driver with 2A output 

 

Body Image 2-ADI-IGG-Reference-Designs-for-Life-Science


Table of Recommended Parts: Power Management


Function
Part Number
Design Consideration

Micromodule switching reg

 LTM4622
 LTM4623
 

 

 6mm x 6mm micromodule switching
 regulators. Dual/Single 2A/3A output regulator

Buck & Boost Converters

 LTC3388
 LT8609
 LTC3125
 LTC8330
 LT3757





 Buck Regulator with nanoamp Iq.
 Ideal for battery Silent Switcher II, low
 Iq, low noise, 2A output I, 3A peak I.
 Input current limited boost converter,
 ideal for battery Tiny 2x3mm Boost
 converter with 1A, 60V switch
 Switching regulator controller, ideal for
 battery applications

Linear Regulators

 LT3010
 ADP121
 Micropower Linear Regulator. 150mA
 output  I low Iq,
 Negative Linear Regulator. 150mA
 output I, low Iq,
 Micropower Linear Regulator. 150mA
 output I, low Iq.

Battery Management

 LTC4412
 LTC4100
 LT6700
 SOT-23 auto switchover between battery
 and main power
 Smart Battery Charger Controller
 Micropower battery monitor. (SOT23
 and 2x3mm DFN)

 

Surge Stopper

 LT4356  Surge stopper, allows power supplies to
 ride through voltage surges 

Charge Pump Inverter

 LTC1983-x  Simple -3V/-5V supply for amp bias

 

IVD - In Vitro Diagnostics

IVD devices are an important tool for doctors to use during the process of helping patients get healthy. The IVD process allows for a small tissue sample to be removed from a patient, then analyzed in one of a few different types of machines. Depending on the outcome of the analysis, the patient can be discharged, prescribed treatment, or requested to undergo further testing. IVD devices are well established, but there are a few market trends currently underway:

  • •  POC (point-of-care) diagnostics are making IVD equipment more widely available at clinics and also in patients’ homes
  • •  In Vivo diagnostics enable testing without having to remove any tissue samples. This is accomplished through use of wearable or implantable devices
  • •  Increased levels of automation allow for quicker, more accurate, and less labor-intensive testing

There are a few different categories of commonly used IVD diagnostics:

  • •  Chemical: Analyte detection determines if substances, such as glucose, lactate, cholesterol, etc., are present and at normal levels
  • •  Hematological: Blood testing evaluates things such as blood count, blood quality, protein levels, and presence of any bloodborne illnesses
  • •  Microbiological: Infectious disease testing evaluates a sample for the presence of bacteria, viruses, parasites, fungi, or antibodies
  • •  Molecular: DNA testing looks for abnormalities or variation in genetic code, and determines predisposition for certain diseases

In the following flow charts and tables, learn about signal chains for typical IVD devices and specialized products from Analog Devices that are ideal for this application.

 

Body Image 3-ADI-IGG-Reference-Designs-for-Life-Science

 

Related Parts

 

Body Image 4-ADI-IGG-Reference-Designs-for-Life-Science

 

Related Parts

 

Kidney Dialysis

Globally, kidney disease is on the rise, leading to a commensurate increase in the need for dialysis treatment devices. These machines, which must be used 3 times per week for up to 4 hours at a time, help filter a patient’s blood to remove any impurities and to maintain an equilibrium of water and minerals in the body. There are two main types of dialysis treatment:

  • •  Hemodialysis uses a filtering machine called a dialyzer, which is external to the patient’s body
  • •  Peritoneal dialysis uses a part of the stomach lining called the peritoneum, coupled with a chemical called dialysate, to clean the patient’s blood. The peritoneum is semi-permeable, so it is able to function as a filter

In the following system schematics and tables, learn more about the layout of typical dialysis machines, and find out how components from Analog Devices can help in the design process.

 

Body Image 5-ADI-IGG-Reference-Designs-for-Life-Science

 

Table of Recommended Parts: Sensor Inputs


Function
Part Number
Design Consideration

Pressure Sensor Interface
(Many sensors used have Digital Interface)

 AD8221 (discrete implementation)
 AD8226
 Instrumentation amp. Single resistor
 gain adjustment
 AD7124-4 (integrated implementation)  Integrated analog front end 
 LTC6915  Zero drift precision in amp
 AD8555
 AD8556
 AD8557 
 Digital Controlled Sensor AFE


 ADA4558  Bridge sensor signal conditioner 

Temperature Sensing

 ADT7420
 ADT7422
 ±02/±0.1°C Accurate, 16-Bit Digital
 I2C Temp Sensor
 ADT5912  0.1°C Accurate Analog Temp Sensor
 AD7124
 AD719x
 24Bit Sigma Delta ADC + Excitation
 

Air bubble detection

 AD5940 (impedance)   High precision impedance front end 
 AD7746 (capacitive)  2 channel capacitance to digital converter
 ADPD1080
 ADPD188BIZ
 Optical Bubble Detect
 (transmissive/reflective)
 

Level Sensing

 ADPD1080 (Optical)   Optical AFE requires external Optics   (PD/LEDs) 
 AD7745 (Capacitive)
 AD7746
 AD7747
 Single/Dual Channel 24Bit Cap Sensing   Technology
 

Conductivity

 AD5940
 ADuCM355
 Single AFE / Full Integrated Impedance   Front-end

Table of Recommended Parts: Vital Parameter Tracking


Function
Part Number
Design Consideration

ECG Monitoring

 AD8233  Single LEAD ECG Front-End
 ADAS1000-3
 ADAS1000-4
 3 LEAD Diagnostic Performance ECG   Monitor 
 AD8220
 AD8422 + ADAQ7980
 Discrete Built ECG Front End
 AD8244 / ADA4528-x

 High Impedance Buffer / Zero Drift
 Amplifier

Optical Sensing

 ADPD1080 /ADPD4000  Optical Heart-Rate AFE for
 Transmissive and Reflective Based
 Systems
 ADPD188GGZ  Reflective Heart-Rate at the Wrist
 ADPD144RIZ  Optical Heart-Rate in the Ear 

EDA/GSR/BIA

 AD5940
 ADuCM350
 ADuCM355
 Impedance Sensing for Stress Monitoring   (sensors at Wrist or Fingers), Sensing Body
 Composition / Body Fluids (Sensors on   Limbs / on Chest)
 

Blood Pressure

 AD8233 + ADPD1080 (Optical)   Ventricle Contraction + Optical AFE to
 detect Pulse Arrival Time
 
 ADxL355 + ADuCM350 (Optical)   Ballistocardiograph + Optical AFE to
 detect Pulse Arrival Time
 

Body Temperature 

 ADT7422 / ADT5912
 AD7124 / AD719x
 Digital Temperature Sensor requires
 Heat Flux
 24 Bit Sigma Delta ADC

Table of Recommended Isolation Products


Function
Part Number
Design Consideration

Digital Isolators

 ADuM220ADuM221
 ADuM240ADuM241ADuM242

 ADuM260ADuM261ADuM262,
 ADuM263
 Improved Radiated Emissions
 performance, & Surge capability

Digital Isolators + Power

 Late 2019:
 ADuM6420A
 ADuM6421A
 ADuM6422A
 ADuM6423A
 Improved Radiated Emissions
 performance


Power Only

 ADuM6020
 ADuM6028
 Improved Radiated Emissions performance

USB Isolator

 ADuM4160
 In 2020: ADuM4165



 ADuM4160 will likely have emissions   challenges
 ADuM4165 designed for low emissions
 and high surge

Isolated USB Transceiver with isolated power

 LTM2884


 2500Vrms Isolation, integrated DC/DC   converter, and auto configuration of bus   speed 

Isolated RS-232

 Discrete Approach: Digital Isolator +   Transceiver  ADM32512E only 2.5 kVrms, no IEC
 60601-1 certification

Isolated RS-485

 Today: ADM2490E
 ADM2481E
 5 kVrms but no IEC 60601-1 certification 

Isolated RS-485 + Power

 ADM2682E / ADM2687E or LTM2885
 Late 2019: ADM2867E
 
 ADM2682E/87E 5 kVrms but has no
 IEC 60601-1 certification and will likely
 have emissions challenges.
 ADM2867E designed for low emissions
 LTM2885 has exceptional EMC
 performance and high surge

 

 

Body Image 6-ADI-IGG-Reference-Designs-for-Life-Science


Table of Recommended Power Parts


Function
Part Number
Design Consideration

Micromodule switching reg

 LTM4622
 LTM4623

 6mm x 6mm micromodule switching   regulators. Dual/Single 2A/3A output   regulator

Buck & Boost Converters

 LTC3388
 LT8609
 LTC3125
 LTC8330
 LT3757



 Buck Regulator with nanoamp Iq. Ideal
 for battery Silent Switcher II, low Iq,
 low noise, 2A output I, 3A peak I.
 Input current limited boost converter,
 ideal for battery Tiny 2x3mm
 Boost converter with 1A, 60V switch
 Switching regulator controller, ideal for   battery applications

Linear Regulators

 LT3010
 ADP121



 Micropower Linear Regulator. 150mA
 output I low Iq, Negative Linear
 Regulator. 150mA output I, low Iq.
 Micropower Linear Regulator. 150mA
 output I, low Iq.
 LT3757

 Switching regulator controller, ideal for   battery applications

Battery Management

 LTC4412
 LTC4100
 LT6700


 SOT-23 auto switchover between
 battery and main power
 Smart Battery Charger Controller
 Micropower battery monitor. (SOT23
 and 2x3mm DFN)

Surge Stopper

 LT4356  Surge stopper, allows power supplies to
 ride through voltage surges

Charge Pump Inverter

 LTC1983-x   Simple -3V/-5V supply for amp bias 

 

Infusion Pumps

Infusion pumps are becoming increasingly common in the medical field. They allow for controlled administration of things such as nutrients or medications to a patient’s body. Key drivers of this expanding market include:

  • •  The rise of chronic disease, in turn driving the need for more pumps and new pump technologies
  • •  Reduction of errors such as over-administration of medication or pump malfunction

Proper dosing of medication is critical for patient care, so it’s imperative that new pumps must be highly accurate, simple to use, universally understood (between disparate hospital systems), and compliant with all applicable guidelines and regulations. The need for higher-tech, more reliable and accurate pumps has driven designers to seek out better components for their products. Analog Devices manufactures components that are particularly suited to the demands of this application, find out more below.

 

Body Image 7-ADI-IGG-Reference-Designs-for-Life-Science

 

Table of Recommended Parts


Function
Part Number
Design Consideration

Pressure Sensor Interface

 AD8226 (discrete implementation)

 Instrumentation amp. Single resistor
 gain adjustment
 AD7124-4 (integrated implementation)  Integrated analog front end 
 LTC6915  Zero drift precision in amp 
 ADA4558  Bridge sensor signal conditioner

Optical Drip Detection

 ADPD1080  Highly efficient photometric front end

Air bubble detection

 AD5940 (impedance)  High precision impedance front end
 AD7746 (capacitive)  2 channel capacitance to digital converter

Temp Sensor

 ADT7420  ±0.25°C Accurate, 16-Bit Digital I2C
  Temp Sensor
 

Drop and Shock

 ADXL375   3-Axis, ±200 g Digital MEMS   Accelerometer  

General Purpose Amps

 ADA4841  Very low noise and distortion, 80MHz   GBW
 LT1991  Use for inverting an non-inverting amp,   100uA Iq 
 AD8237 / AD8277   Very easy to use diff amp with
 106dB/86dB
 CMRR
 

 

Table of Recommended Isolation Products


Function
Part Number
Design Consideration

Digital Isolators

 ADuM220ADuM221
 ADuM240ADuM241ADuM242

 ADuM260ADuM261ADuM262,
 ADuM263
 Improved Radiated Emissions
 performance, & Surge capability

Digital Isolators + Power

 Late 2019:
 ADuM6420A
 ADuM6421A
 ADuM6422A
 ADuM6423A
 Improved Radiated Emissions
 performance


Power Only

 ADuM6020
 ADuM6028
 Improved Radiated Emissions performance

USB Isolator

 ADuM4160
 In 2020: ADuM4165



 ADuM4160 will likely have emissions   challenges
 ADuM4165 designed for low emissions
 and high surge

Isolated USB Transceiver with isolated power

 LTM2884


 2500Vrms Isolation, integrated DC/DC   converter, and auto configuration of bus   speed 

Isolated RS-232

 Discrete Approach: Digital Isolator +   Transceiver  ADM32512E only 2.5 kVrms, no IEC
 60601-1 certification

Isolated RS-485

 Today: ADM2490E
 ADM2481E
 5 kVrms but no IEC 60601-1 certification 

Isolated RS-485 + Power

 ADM2682E / ADM2687E or LTM2885
 Late 2019: ADM2867E
 
 ADM2682E/87E 5 kVrms but has no
 IEC 60601-1 certification and will likely
 have emissions challenges.
 ADM2867E designed for low emissions
 LTM2885 has exceptional EMC
 performance and high surge

 

 

Body Image 8-ADI-IGG-Reference-Designs-for-Life-Science


Table of Recommended Parts: Power Management


Function
Part Number
Design Consideration

Micromodule switching reg

 LTM4622
 LTM4623
 
 6mm x 6mm micromodule switching   regulators. Dual/Single 2A/3A output   regulator

Buck & Boost Converters

 LTC3388
 LT8609
 LTC3125
 LTC8330
 LT3757



 Buck Regulator with nanoamp Iq. Ideal
 for battery 
Silent Switcher II, low Iq,
 low noise, 2A output I, 3A peak I.
 Input current limited boost converter,
 ideal for battery Tiny 2x3mm
 Boost converter with 1A, 60V switch
 Switching regulator controller, ideal for
 battery applications

Linear Regulators

 LT3010
 ADP121
 LT3757
 Micropower Linear Regulator. 150mA
 output I low Iq,
 Negative Linear Regulator. 150mA
 output I, low Iq,
 Micropower Linear Regulator. 150mA
 output I, low Iq.
 Switching regulator controller, ideal for
 battery applications

Battery Management

 LTC4412
 LTC4100
 LT6700
 SOT-23 auto switchover between
 battery and main power
 Smart Battery Charger Controller
 Micropower battery monitor. (SOT23
 and 2x3mm DFN)

Surge Stopper

 LT4356   Surge stopper, allows power supplies to
 ride through voltage surges

Charge Pump Inverter

 LTC1983-x  Simple -3V/-5V supply for amp bias

 

 

Latest News

Sorry, your filter selection returned no results.

We've updated our privacy policy. Please take a moment to review these changes. By clicking I Agree to Arrow Electronics Terms Of Use  and have read and understand the Privacy Policy and Cookie Policy.

Our website places cookies on your device to improve your experience and to improve our site. Read more about the cookies we use and how to disable them here. Cookies and tracking technologies may be used for marketing purposes.
By clicking “Accept”, you are consenting to placement of cookies on your device and to our use of tracking technologies. Click “Read More” below for more information and instructions on how to disable cookies and tracking technologies. While acceptance of cookies and tracking technologies is voluntary, disabling them may result in the website not working properly, and certain advertisements may be less relevant to you.
We respect your privacy. Read our privacy policy here